NanoBase™ Epilingual is a custom nanoscale delivery Architecture engineered for bioavailability in consumable formats, built around your actives with one, two, or three delivery domains. Load it yourself active-free, or let our lab formulate your actives into it. Every build is engineered for its own program: pharmaceutical, dietary supplement, or nutricosmetic.
The problem
Topical formulation is migrating off 1949 HLB emulsion physics onto nanoscale architecture. Consumable delivery has the same legacy problem and has moved slower. In conventional powders, standard capsules, and macro-scale emulsified actives, fine and even dispersion of the active is harder to achieve.
Formulators often over-formulate to compensate, which adds cost. The same architectural shift moving topical formulation onto nanoscale Architecture is now reaching consumables.
The Architecture
NanoBase™ Epilingual is not an off-the-shelf liposome or nanoemulsion. Every consumable chassis is customized: we select the delivery domains your actives need and combine them in one chassis, designed to an electrostatic (DLVO) stabilisation specification.
Lipid nanodroplets designed to host oil-soluble actives and carry a meaningful lipid payload.
Bilayer vesicles. The bilayer hosts amphiphilic and lipophilic actives; the aqueous core can encapsulate water-soluble actives loaded during vesicle formation.
Micelles designed to solubilize poorly water-soluble and surface-active actives into a clear aqueous phase.
One domain when one is enough. Two or three when the active set spans oil-soluble, amphiphilic, and water-soluble materials. The domain set is engineered to the actives, not the other way around. That is what separates NanoBase™ Epilingual from fixed, single-architecture consumable delivery systems. Partitioning into the domains is by design and is confirmed by the formulator on the finished product.
The NanoBase™ Architecture is developed at Pensive Beauty® Nanoscience Labs, where the underlying delivery science is documented.
Bioavailability
For most consumable actives, the dose taken is not the dose that reaches circulation. Bioavailability is lost at three barriers: dissolution, the mucosal surface, and first-pass metabolism. NanoBase™ Epilingual is engineered against each one, and every build is configured to the barrier that limits your active.
Barrier 1
A poorly water-soluble active has to dissolve before it can be absorbed, and for many actives that step sets the ceiling. Epilingual's lipid domains are designed to present lipophilic actives already solubilized, not as crystals or coarse powder. Interfacial area scales with 6/d: a 50 nm population carries 40× the surface area of a 2 µm macro-emulsion, and 4× that of a 200 nm population.
Barrier 2
Sublingual and buccal absorption depends on contact with the mucosa. Conventional dosage forms can reduce that contact, leading to unpredictable absorption (Hua, 2019). Epilingual mucosal builds pair nanoscale particle size with isotonic osmolality and a polyol phase built for hold time. Non-adhesive nanoparticles a few hundred nanometres across have been shown to move rapidly through fresh human mucus (Lai et al., 2007).
Barrier 3
There are two routes around the liver. Sublingual and buccal absorption drains directly to the systemic circulation via the superior vena cava (Hua, 2019). For swallowed builds, lipid-based formulations can recruit intestinal lymphatic transport, which can protect lipophilic actives from first-pass metabolism; long-chain, unsaturated lipids are especially effective (Porter, Trevaskis & Charman, 2007). Lipid selection is set per program.
The chassis
The interfacial system is selected for each program, not fixed. Where phospholipids suit the active, a build can draw on one of the most studied carrier classes for raising the absorption of poorly absorbed botanicals and vitamins. Every build adds nanoscale size control and a domain set configured to your actives.
Third-party human and review data on phospholipid and lipid carriers. These are not NanoBase™ Epilingual results.
Our job
We design the domain set, route, and particle size to your bioavailability target, formulate your actives into the build if you want us to, and robustness-test it so it holds up.
Your job
All final testing is your responsibility, through a lab qualified to complete any testing and substantiate any claim you wish to make, including absorption and bioavailability.
Delivery route
It all depends on what the program is trying to accomplish. Route, domain set, and particle size are designed together, with particle size engineered as low as 50 nm.
Sublingual and buccal builds are designed to be held under the tongue or against the cheek, presenting the active to the oral mucosa for absorption across the mucous membranes, bypassing the digestive tract. Nanoscale particle size, isotonic osmolality, and a palatable polyol phase built for hold time.
Oral builds are designed to be swallowed, carrying the active to the digestive tract as a fine, uniform nanoscale dispersion rather than a coarse powder or macro-emulsion.
Route, domain set, and particle size are set by what the client wants to achieve, and each build is robustness-tested against that program's specification. All final testing, including absorption and bioavailability, is the client's responsibility through a qualified lab.
Two ways to work
NanoBase™ Epilingual ships as a self-complete, active-free Architecture configured to your program. You do not rebuild matrix functions it already contains. Your actives are blended in at room temperature at your end.
Prefer we handle it? Our lab formulates your actives into the build, from domain design and flavor, sweetener, and cooling systems through robustness testing, and delivers the finished formulation.
Each build is engineered for its market: pharmaceutical, dietary supplement, or nutricosmetic. Your finished product, your positioning.
What you make, how you validate it, and how you classify it are yours to control.
Example build
A two-domain reference build (nanoemulsion and vesicular) for dropper and sublingual formats, shown here without actives. Mint Cooling is one example; every program is configured to its own actives and flavor.
Part A is the NanoBase™ core with its domains already formed. Part B is the polyol phase carrying sweetener, mint flavor, cooling agents, and a thickening polymer.
Your active goes into Part B at room temperature. Part B is then combined with Part A under gentle mixing and brought to final weight with purified water. No heat and no sonication at your end.
Measured on the assembled batch. Values depend on the active and its load and are verified by the formulator.
Who it serves
A custom nanoscale carrier engineered for your oral or sublingual program, supplied active-free so your team formulates and validates your own actives under your own protocols. Or our lab formulates them for you.
A custom alternative to single-architecture liposomal systems for functional ingredients, adaptable across sublingual and oral consumable formats.
For beauty-from-within and ingestible-beauty brands. Collagen peptides, hyaluronic acid, ceramides, astaxanthin, and polyphenols are often absorption-limited; each build is engineered around them in drops, shots, sublingual, and oral formats.
Questions
Custom nanoscale delivery technology for oral and sublingual consumable formats, configured with one, two, or three delivery domains to host each program's actives. It is engineered per program, for pharmaceutical, dietary-supplement, or nutricosmetic development, and supplied active-free for your team to load, or formulated with your actives by our lab.
A standard liposomal carrier is one fixed architecture, whatever the active. NanoBase™ Epilingual is engineered around the active set: nanoemulsion, vesicular, and micellar domains are selected and combined as the program requires, in one chassis designed to an electrostatic (DLVO) stabilisation specification.
No. Every consumable chassis is customized. Domain count, format, and flavor, sweetener, and cooling systems are set per program to host your actives.
None of these on its own. It is delivery technology, supplied active-free or formulated with your actives. The regulatory classification of any finished product and its clinical or regulatory validation are the responsibility of the developing party.
It is engineered for it. Each build targets the barrier that limits the active: dissolution, the mucosal surface, or first-pass metabolism. How much a finished product achieves depends on the active and is substantiated by the client through a qualified lab.
Yes. Ingestible-beauty actives such as collagen peptides, hyaluronic acid, ceramides, astaxanthin, and polyphenols are often absorption-limited. Each build is engineered around them, for drops, shots, sublingual, or oral formats.
Yes. Load the active-free chassis yourself, or have our lab formulate your actives into the build, through robustness testing, and deliver the finished formulation.
We handle nanoformulation and robustness testing. All final testing and claim substantiation is the client's responsibility, through a lab qualified to complete any testing or claims they wish to substantiate.
Yes. Sublingual and buccal builds are designed for absorption across the oral mucous membranes, bypassing the digestive tract. Oral builds can instead be designed to be swallowed and reach the digestive tract. Route is set by what the program is trying to accomplish.
Particle size is engineered per program, as low as 50 nm. The Mint Cooling reference build targets 150–200 nm.
Oral, sublingual, and buccal consumable formats. Each chassis is configured to the program, then either loaded at room temperature at your end or formulated with your actives by our lab.
Yes. Request a program brief and we will start in writing so every detail is exact and on record.
Get started
Tell us the format and the actives you are developing. We work in writing so every claim stays exact and substantiated.
Email team@pensivebeauty.com